{"id":51,"date":"2022-10-10T15:08:48","date_gmt":"2022-10-10T06:08:48","guid":{"rendered":"https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/?page_id=51"},"modified":"2022-11-28T14:47:57","modified_gmt":"2022-11-28T05:47:57","slug":"technology","status":"publish","type":"page","link":"https:\/\/cytopathfinder.com\/ja\/business\/technology\/","title":{"rendered":"\u6280\u8853\u7d39\u4ecb"},"content":{"rendered":"<p><!------------------------------------\n\u57fa\u76e4\u6280\u8853\n------------------------------------><\/p>\n<section class=\"mb100\">\n<h2 class=\"styled_h3\">\u57fa\u76e4\u6280\u8853<\/h2>\n<p><!------------------------------------\n\u56fa\u76f8\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3STF\u306e\u6982\u8981\n------------------------------------><\/p>\n<div class=\"mb80\">\n<p class=\"lead\">\u56fa\u76f8\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3STF\u306e\u6982\u8981<\/p>\n<p>\u6838\u9178\u3092\u30ac\u30e9\u30b9\u30a2\u30ec\u30a4\u53c8\u306f\u7d30\u80de\u57f9\u990a\u6a39\u8102\u30d7\u30ec\u30fc\u30c8\u4e0a\u306b\u56fa\u76f8\u5316\u3057\u3066\u3001\u7d30\u80de\u3078\u306e\u6838\u9178\u5c0e\u5165\u3092\u5bb9\u6613\u306b\u3059\u308b\u6280\u8853\u306f\u30012000\u5e74\u4ee3\u521d\u982d\u306b\u5f0a\u793e\u5275\u696d\u8005\u306e\u4e00\u4eba\u3067\u3042\u308b\u7814\u7a76\u8005\u304c\u7c73\u56fd\u3000\u30b9\u30af\u30ea\u30d7\u30b9\u7814\u7a76\u6240\u3067\u958b\u767a\u7279\u8a31\u5316\u3057\u3001\u305d\u306e\u5f8c\u9032\u5316\u3055\u305b\u3066\u304d\u305f\u6280\u8853\u3067\u3059\u3002\u305d\u308c\u307e\u3067\u306b\u306a\u304b\u3063\u305f\u9769\u65b0\u7684\u306a\u70b9\u306f\u3001\u7d30\u80de\u306e\u98df\u4f5c\u7528\uff08\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff09\u3092\u4fc3\u9032\u3059\u308b\u5c0e\u5165\u4fc3\u9032\u5264\u3092\u898b\u51fa\u3057\u56fa\u76f8\u5316\u6280\u8853\u3068\u3057\u3066\u7279\u8a31\u5316\u3057\u305f\u3053\u3068\u306b\u59cb\u307e\u308a\u307e\u3059\u3002<br \/>\n\u3053\u306e\u6280\u8853\u306f\u4e00\u822c\u7684\u306a\u682a\u5316\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u907a\u4f1d\u5b50\u5c0e\u5165\u304c\u96e3\u3057\u3044\u3068\u3055\u308c\u3066\u3044\u308b\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u30fb\u5e79\u7d30\u80de\u306a\u3069\u5404\u7a2e\u7d30\u80de\u306b\u3082\u9069\u7528\u53ef\u80fd\u3067\u3059\u3002\u307e\u305f\u3001\u5f93\u6765\u306f\u719f\u7df4\u306e\u7814\u7a76\u8005\u306b\u3088\u308a\u5bb9\u5668\u5185\/\u6eb6\u6db2\u4e2d\u3067\u6838\u9178\u5c0e\u5165\u3055\u308c\u3066\u3044\u305f\u7d30\u80de\u5b9f\u9a13\u30d7\u30ed\u30bb\u30b9\u304c\u3001\u6700\u9069\u914d\u5408\u3055\u308c\u305f\u6838\u9178\u3068\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u8a66\u85ac\u3001\u66f4\u306b\u5c0e\u5165\u4fc3\u9032\u5264\u306e\u8907\u5408\u4f53\u304c\u3001\u5f0a\u793e\u3067\u3042\u3089\u304b\u3058\u3081\u57f9\u990a\u30d7\u30ec\u30fc\u30c8\u4e0a\u306b\u81ea\u52d5\u5316\u88c5\u7f6e\u3067\u56fa\u76f8\u5316\u51e6\u7406\u3055\u308c\u3001\u5de5\u696d\u7684\u306a\u5546\u54c1\u3068\u3057\u3066\u9867\u5ba2\u306b\u7d0d\u5165\u3055\u308c\u3001\u9867\u5ba2\u3067\u306f\u5358\u306b\u76ee\u7684\u306e\u7d30\u80de\u3092\u64ad\u7a2e\u3059\u308b\u3060\u3051\u306e\u7c21\u5358\u306a\u4f5c\u696d\u3067\u6b63\u78ba\u306a\u5b9f\u9a13\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u308b\u3068\u3044\u3046\u3001\u5f93\u6765\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u98db\u8e8d\u7684\u306b\u7c21\u6613\u5316\u30fb\u52b9\u7387\u5316\u3057\u305f\u907a\u4f1d\u5b50\u5c0e\u5165\u3068\u7d30\u80de\u57f9\u990a\u30d7\u30ed\u30bb\u30b9\u3092\u5b9f\u73fe\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<p><!------------------------------------\n\u5f93\u6765\u306e\u56fa\u76f8\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u3068\u305d\u306e\u8ab2\u984c\n------------------------------------><\/p>\n<div class=\"mb80\">\n<p class=\"lead\">\u5f93\u6765\u306e\u56fa\u76f8\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u3068\u305d\u306e\u8ab2\u984c<\/p>\n<p>\u5f93\u6765\u306e\u6db2\u76f8\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u3067\u306f\u3001\u7d30\u80de\u3092\u30c7\u30d0\u30a4\u30b9\u4e0a\u3067\u524d\u57f9\u990a\u3057\u3066\u304b\u3089\u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u8a66\u85ac\u3092\u6dfb\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u624b\u6cd5\u306f\u64cd\u4f5c\u304c\u7169\u96d1\u306a\u4e0a\u3001\u907a\u4f1d\u5b50\u5c0e\u5165\u52b9\u7387\u304c\u4f4e\u3044\u3068\u3044\u3046\u554f\u984c\u304c\u3042\u308a\u307e\u3057\u305f\u3002<br \/>\n\u305d\u3053\u3067\u3001\u30c7\u30d0\u30a4\u30b9\u306e\u56fa\u76f8\u4e0a\u306b\u5c0e\u5165\u3059\u308b\u907a\u4f1d\u5b50\u3092\u56fa\u5b9a\u5316\u3057\u3001\u305d\u306e\u4e0a\u3067\u7d30\u80de\u3092\u57f9\u990a\u3059\u308b\u3060\u3051\u3067\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u3092\u884c\u3046\u56fa\u76f8\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u304c\u958b\u767a\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u4ee3\u8868\u7684\u306a\u3082\u306e\u306b\u3001\u30a6\u30a7\u30eb\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\uff08Homma K\u3089 BBRC, 2001, 289, 1075-1081) \u3084\u3001\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\uff08Ziauddin J and Sabatini DM Nature, 2001, 411, 107-110)\u306b\u3088\u308b\u56fa\u76f8\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u6280\u8853\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u3053\u308c\u3089\u306e\u65b9\u6cd5\u3067\u306f\u30d7\u30ed\u30c8\u30b3\u30eb\u306f\u7c21\u4fbf\u5316\u3055\u308c\u305f\u3082\u306e\u306e\u3001\u591a\u304f\u306e\u7d30\u80de\u7a2e\u306b\u304a\u3044\u3066\u907a\u4f1d\u5b50\u5c0e\u5165\u52b9\u7387\u304c\u4f4e\u3044\u3068\u3044\u3046\u554f\u984c\u304c\u4f9d\u7136\u3068\u3057\u3066\u89e3\u6c7a\u3055\u308c\u3066\u3044\u306a\u3044\u305f\u3081\u3001\u9069\u7528\u3067\u304d\u308b\u7d30\u80de\u7a2e\u304c\u5236\u9650\u3055\u308c\u308b\u6b20\u70b9\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<p><!------------------------------------\n\u8ab2\u984c\u89e3\u6c7a\u306e\u305f\u3081\u306e\u5f53\u793e\u6280\u8853\n------------------------------------><\/p>\n<div class=\"mb80\">\n<p class=\"lead\">\u8ab2\u984c\u89e3\u6c7a\u306e\u305f\u3081\u306e\u5f53\u793e\u6280\u8853<\/p>\n<p>\u5f53\u793e\u306e\u5275\u696d\u30e1\u30f3\u30d0\u30fc\u3067\u3042\u308b\u4e09\u5b85\u6b63\u4eba\uff08\u5de5\u5b66\u535a\u58eb\uff09\u306f\u3001\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30af\u30b9\u30bf\u30f3\u30d1\u30af\u8cea\uff08*\uff09\u306a\u3069\u306e\u300c\u907a\u4f1d\u5b50\u5c0e\u5165\u4fc3\u9032\u5264\u300d\u3092\u7528\u3044\u308b\u72ec\u81ea\u306e\u56fa\u76f8\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u6280\u8853\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u5c0e\u5165\u52b9\u7387\u3092\u98db\u8e8d\u7684\u306b\u9ad8\u3081\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<br \/>\n\u907a\u4f1d\u5b50\u5c0e\u5165\u4fc3\u9032\u5264\u306e\u958b\u767a\u306b\u3088\u308a\u3001\u9069\u7528\u53ef\u80fd\u306a\u7d30\u80de\u7a2e\u304c\u5e83\u304c\u308a\u3001\u907a\u4f1d\u5b50\u5c0e\u5165\u52b9\u7387\u304c\u4f4e\u304f\u3066\u304a\u60a9\u307f\u306e\u7d30\u80de\u3067\u306e\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u5b9f\u9a13\u3092\u53ef\u80fd\u306b\u3057\u307e\u3057\u305f\u3002<br \/>\n*\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30af\u30b9\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u308b\u907a\u4f1d\u5b50\u5c0e\u5165\u4fc3\u9032\u4f5c\u7528\u306b\u3064\u304d\u307e\u3057\u3066\u306f\u3001\u7d30\u80de\u5185\u30b9\u30c8\u30ec\u30b9\u30d5\u30a1\u30a4\u30d0\u30fc\u8a98\u5f15\u4f5c\u7528\u304c\u5f15\u304d\u91d1\u3068\u306a\u3063\u3066\u3001\u7d30\u80de\u3068DNA(RNA)\u5c64\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u5897\u5f37\u3055\u308c\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u307e\u3059(Yoshikawa T, et. al., J. Control Release, 2004, 96, 227-232 ; Uchiyama E, et al., Neuroscience Lett., 2005, 378, 40-43)<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology01.jpg\" alt=\"Transfection Array\u306e\u56f3\" width=\"655\" height=\"660\" class=\"aligncenter size-full wp-image-175\" srcset=\"https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology01.jpg 655w, https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology01-298x300.jpg 298w, https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology01-150x150.jpg 150w\" sizes=\"auto, (max-width: 655px) 100vw, 655px\" \/>\n<\/div>\n<p><!------------------------------------\n\u9069\u7528\u53ef\u80fd\u306a\u7d30\u80de\u7a2e\n------------------------------------><\/p>\n<div class=\"mb80\">\n<p class=\"lead\">\u9069\u7528\u53ef\u80fd\u306a\u7d30\u80de\u7a2e<\/p>\n<p>\u907a\u4f1d\u5b50\u5c0e\u5165\u4fc3\u9032\u5264\u3092\u7528\u3044\u305f\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u7528\u30c7\u30d0\u30a4\u30b9\u3067\u3042\u308b\u5f53\u793e\u306e\uff62\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u30a2\u30ec\u30a4\u2122\u300d\u306f\u3001\u4e0b\u8868\u306b\u793a\u3055\u308c\u308b\u3088\u3046\u306b\u682a\u5316\u7d30\u80de\u4ee5\u5916\u306b\u3082\u3001\u907a\u4f1d\u5b50\u5c0e\u5165\u304c\u96e3\u3057\u3044\u3068\u3055\u308c\u3066\u3044\u308b\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u3001\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306b\u304a\u3051\u308b\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u3092\u53ef\u80fd\u3068\u3057\u307e\u3057\u305f\u3002<br \/>\n\u5f53\u793e\u3067\u306f\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u5c0e\u5165\u4fc3\u9032\u5264\u3092\u63c3\u3048\u3066\u304a\u308a\u3001\u305d\u306e\u4ed6\u306e\u591a\u304f\u306e\u7d30\u80de\u7a2e\u306b\u304a\u3044\u3066\u3082\u9ad8\u52b9\u7387\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u304c\u53ef\u80fd\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002<br \/>\n\u307e\u305f\u3001\u6d6e\u904a\u7d30\u80de\u306b\u5bfe\u3057\u3066\u3082\u3001\u4f8b\u3048\u3070\u3001Kato K\u3089\u306b\u3088\u308a(Biotechniques, 2004, 37, 444-452)\u3001BAM\uff08Biocompatible anchor for membrane\uff09\u3067\u4fee\u98fe\u3057\u305f\u30c7\u30d0\u30a4\u30b9\u8868\u9762\u3067\u7d30\u80de\u3092\u4fdd\u6301\u3059\u308b\u65b9\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u304a\u308a\u3001\u6d6e\u904a\u7d30\u80de\u682aK562 \u7d30\u80de\u3067\u306e\u56fa\u76f8\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u5f53\u793e\u306e\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u30a2\u30ec\u30a4\u2122\u304c\u4ed8\u7740\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u6d6e\u904a\u7d30\u80de\u306b\u3082\u9069\u7528\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n<\/div>\n<p><!------------------------------------\n\u8868\n------------------------------------><\/p>\n<section class=\"mb100 technology-table\">\n<table class=\"table-bottom\" style=\"width: 100%;\">\n<tbody>\n<tr>\n<td class=\"table-bottom-td-r table-ti\">Applicable Cells<\/td>\n<td class=\"table-bottom-td-l table-ti\">Source<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">Cell lines<\/td>\n<td class=\"table-bottom-td-l\"><\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">Hela<\/td>\n<td class=\"table-bottom-td-l\">human cervix carcinoma<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">T-47D<\/td>\n<td class=\"table-bottom-td-l\">human breast cancer<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">SK-BR-3<\/td>\n<td class=\"table-bottom-td-l\">human breast cancer<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">MCF7<\/td>\n<td class=\"table-bottom-td-l\">human breast cancer<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">MDA-MB-231<\/td>\n<td class=\"table-bottom-td-l\">human breast cancer<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">MDA-MB-453-S<\/td>\n<td class=\"table-bottom-td-l\">human breast cancer<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">HEK293, 293T<\/td>\n<td class=\"table-bottom-td-l\">human embryonic kidney<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">Caco2<\/td>\n<td class=\"table-bottom-td-l\">adenocarcinoma, colon<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">HepG2<\/td>\n<td class=\"table-bottom-td-l\">human hepatocellular carcinoma<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">NT2 (NTERA-2)<\/td>\n<td class=\"table-bottom-td-l\">human teratocarcinoma<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">SHSY5Y<\/td>\n<td class=\"table-bottom-td-l\">human neuroblastoma<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">NIH\/3T3, 3T3-L1<br \/>PC-12<\/td>\n<td class=\"table-bottom-td-l\">mouse embryonic fibroblast<br \/>rat pheochromocytoma<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">Normal cells<\/td>\n<td class=\"table-bottom-td-l\">rat brain cortex neuronal cells<br \/>primary mouse embryonic fibroblast (MEF)<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">Human breast cancer cells<\/td>\n<td class=\"table-bottom-td-l\">Mice Bearing human tumor xenografts<\/td>\n<\/tr>\n<tr>\n<td class=\"table-bottom-td-r\">Stem cells<\/td>\n<td class=\"table-bottom-td-l\">human mesenchymal stem cell (hMSCs)<br \/>mouse neuronal stem cell<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<p><!------------------------------------\nsiRNA\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u3068\u81e8\u5e8a\u958b\u767a\u306b\u304a\u3051\u308b\u305d\u306e\u5fdc\u7528\n------------------------------------><\/p>\n<div class=\"mb80\">\n<p class=\"lead\">siRNA\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u3068\u81e8\u5e8a\u958b\u767a\u306b\u304a\u3051\u308b\u305d\u306e\u5fdc\u7528<\/p>\n<p class=\"mb50\">siRNA\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u5b9f\u9a13\u306f\u3001\u4e0b\u56f3\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305fsiRNA\u304c\u5bfe\u5fdc\u3059\u308b\u907a\u4f1d\u5b50\u914d\u5217\u3092\u5207\u65ad\u3059\u308b\u3053\u3068\u3067\u3001\u3044\u308f\u3086\u308b\u30ed\u30b9\u30fb\u30aa\u30d6\u30fb\u30d5\u30a1\u30f3\u30af\u30b7\u30e7\u30f3\uff08\u907a\u4f1d\u5b50\u6a5f\u80fd\u306e\u6b20\u5931\uff09\u3092\u60f9\u304d\u8d77\u3053\u3059\u73fe\u8c61\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6280\u8853\u306f\u3001\u682a\u5316\u7d30\u80de\u30fb\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u30fb\u5e79\u7d30\u80de\u306a\u3069\u5404\u7a2e\u306e\u7d30\u80de\u306b\u9069\u7528\u3067\u304d\u3001\u305d\u308c\u3089\u306e\u7d30\u80de\u306b\u304a\u3051\u308b\u3001\u85ac\u5264\u7b49\u306b\u3088\u308b\u523a\u6fc0\u304b\u3089\u8868\u73fe\u578b\u306e\u5909\u5316\u307e\u3067\u306e\u9593\u306b\u6a2a\u305f\u308f\u308b\u30d6\u30e9\u30c3\u30af\u30dc\u30c3\u30af\u30b9\u3092\u8997\u304f\u3053\u3068\u3067\u7d30\u80de\u5185\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u4e0a\u306e\u95a2\u9023\u907a\u4f1d\u5b50\u7fa4\u3092\u7db2\u7f85\u7684\u306b\u6d17\u3044\u51fa\u3057\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology02.jpg\" alt=\"siRNA\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u3068\u81e8\u5e8a\u958b\u767a\u306b\u304a\u3051\u308b\u305d\u306e\u5fdc\u7528\u306e\u753b\u50cf\" width=\"585\" height=\"450\" class=\"aligncenter size-full wp-image-178\" srcset=\"https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology02.jpg 585w, https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology02-300x231.jpg 300w\" sizes=\"auto, (max-width: 585px) 100vw, 585px\" \/><\/p>\n<p>\u5f53\u793e\u306e\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u6280\u8853\u306f\u3001\u4ee5\u4e0b\u306b\u793a\u3059\u3088\u3046\u306b\u533b\u85ac\u54c1\u5019\u88dc\u306e\u63a2\u7d22\u7814\u7a76\u304b\u3089\u81e8\u5e8a\u958b\u767a\u307e\u3067\u306e\u3001\u3055\u307e\u3056\u307e\u306a\u30b9\u30c6\u30c3\u30d7\u3067\u5229\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<ol class=\"mb50\">\n<li>\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u63a2\u7d22\u3068\u540c\u5b9a<\/li>\n<li>\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u30d1\u30b9\u30a6\u30a7\u30a4\u306e\u63a2\u7d22\u306b\u3088\u308b\u75be\u60a3\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e<\/li>\n<li>\u85ac\u5264\u306e\u4f5c\u7528\u6a5f\u5e8f\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u7fa4\u306e\u63a2\u7d22\u306b\u3088\u308b\u3001\u7d30\u80de\u30d5\u30a1\u30fc\u30de\u30b3\u30b2\u30ce\u30df\u30af\u30b9(\u7d30\u80dePGx)\u3092\u7528\u3044\u305f\u81e8\u5e8a\u8a66\u9a13\u306e\u6210\u529f\u7387\u306e\u5411\u4e0a<\/li>\n<li>siRNA\u533b\u85ac\uff08\u305f\u3060\u3057\u3001\u3053\u308c\u307e\u3067\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u3082\u591a\u304f\u306e\u5931\u6557\u4f8b\u304c\u3042\u308a\u3001\u6709\u52b9\u306a\u85ac\u7269\u9001\u9054\u30b7\u30b9\u30c6\u30e0DDS\u306e\u78ba\u7acb\u304c\u5fc5\u9808\uff09<\/li>\n<\/ol>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology03.jpg\" alt=\"siRNA Transfection Technology\u306e\u753b\u50cf\" width=\"650\" height=\"328\" class=\"aligncenter size-full wp-image-179\" srcset=\"https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology03.jpg 650w, https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology03-300x151.jpg 300w, https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology03-516x260.jpg 516w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/p>\n<p class=\"mb50\">\u30d3\u30b8\u30cd\u30b9\u4e0a\u306e\u6295\u8cc7\u5bfe\u52b9\u679c\u3068\u3044\u3046\u89b3\u70b9\u3067\u306f\u30013)\u30684)\u306f\u88fd\u85ac\u7523\u696d\u306b\u3068\u3063\u3066\u306f\u4f4e\u30ea\u30b9\u30af\u304b\u3064\u5e02\u5834\u3078\u306e\u51fa\u53e3\u306b\u8fd1\u3044\u305f\u3081\u3001\u6700\u3082\u8208\u5473\u306e\u3042\u308b\u3068\u3053\u308d\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<br \/>\n\u88fd\u85ac\u696d\u754c\u306b\u304a\u3051\u308b\u81e8\u5e8a\u8a66\u9a13\u306e\u6210\u529f\u7387\u306f\u305d\u308c\u305e\u308c\u300165%\uff08\u30d5\u30a7\u30fc\u30baI\uff09\u300135%\uff08\u30d5\u30a7\u30fc\u30baII\uff09\u300160%\uff08\u30d5\u30a7\u30fc\u30baIII\uff09\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u30d5\u30a7\u30fc\u30baII\u306e\u6210\u529f\u7387\u304c\u7279\u306b\u4f4e\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u5931\u6557\u306e52%\uff08\u30d5\u30a7\u30fc\u30baIII\u3067\u306f\u5b9f\u306b72%\u306b\u4e0a\u308a\u307e\u3059\uff09\u304c\u3001\u300c\u85ac\u52b9\u306a\u3057\u300d\u3068\u3044\u3046\u7406\u7531\u306b\u3088\u308b\u3082\u306e\u3067\u3059\u3002\u3053\u306e\u554f\u984c\u306b\u5bfe\u3057\u3001\u5f93\u6765\u306ePGx\u306f\u3001\u533b\u85ac\u54c1\u306e\u5019\u88dc\u5316\u5408\u7269\u3078\u306e\u5fdc\u7b54\u6027\u306e\u9055\u3046\u96c6\u56e3\u3092\u5206\u985e\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u81e8\u5e8a\u8a66\u9a13\u306e\u6210\u529f\u7387\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3092\u72d9\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\n\u4e00\u65b9\u3001\u7d30\u80dePGx\u3067\u306f\u3001\u7d30\u80de\u306e\u8868\u73fe\u578b\u306e\u5909\u5316\u3092\u5b9a\u91cf\u7684\u306b\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u5019\u88dc\u5316\u5408\u7269\u306e\u85ac\u52b9\u306b\u95a2\u308f\u308b\u91cd\u8981\u306a\u7d30\u80de\u5185\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u85ac\u306e\u4f5c\u7528\u306b\u95a2\u308f\u308b\u5019\u88dc\u907a\u4f1d\u5b50\u7fa4\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u7d042\u4e073000\u500b\u3082\u306e\u5168\u30b2\u30ce\u30e0\u907a\u4f1d\u5b50\u304b\u3089\u7d5e\u308a\u8fbc\u3080\u3068\u3053\u308d\u304c\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u3053\u3046\u3057\u3066\u9078\u629e\u3055\u308c\u305f\u5019\u88dc\u907a\u4f1d\u5b50\u7fa4\u306f\u3001\u5f93\u6765\u306e\u81e8\u5e8a\u30c7\u30fc\u30bf\u306ePGx\u89e3\u6790\u3092\u3088\u308a\u78ba\u5b9f\u3067\u52b9\u7387\u7684\u306a\u3082\u306e\u306b\u3057\u307e\u3059\u3002<br \/>\n\u85ac\u306e\u4f5c\u7528\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u304c\u89e3\u660e\u3055\u308c\u308b\u3068\u3001\u305d\u308c\u3089\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u7528\u3044\u3066\u3001\u3088\u308a\u3088\u3044\u6cbb\u7642\u306e\u305f\u3081\u306e\u65e2\u5b58\u85ac\u30fb\u65b0\u898f\u5019\u88dc\u5316\u5408\u7269NCEs\u306e\u4f75\u5408\u5264\u3084\u9069\u5fdc\u62e1\u5927\u306e\u8a2d\u8a08\u3092\u7406\u8ad6\u7684\u306b\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<br \/>\n\u901a\u5e38\u3001\u30d5\u30a7\u30fc\u30baII\u81e8\u5e8a\u8a66\u9a13\u306b\u306f18\uff5e24\u30f6\u6708\u3092\u8981\u3057\u307e\u3059\u304c\u3001\u7d30\u80dePGx\u3067\u306f6\uff5e12\u30f6\u6708\u3067\u5404\u85ac\u5264\u306e\u4f5c\u7528\u6a5f\u5e8f\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u7fa4\u3092\u540c\u5b9a\u3067\u304d\u308b\u306e\u3067\u3001\u5f93\u6765\u306e\u8907\u96d1\u306aSNPs\u89e3\u6790\u306e\u307f\u306b\u3088\u308bPGx\u3092\u3088\u308a\u8fc5\u901f\u3067\u7c21\u4fbf\u306a\u3082\u306e\u306b\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u533b\u85ac\u54c1\u5019\u88dc\u5316\u5408\u7269\u306e\u7d30\u80dePGx\u89e3\u6790\u3092\u30d5\u30a7\u30fc\u30baII\u307e\u305f\u306f\u305d\u308c\u4ee5\u524d\u306b\u884c\u3046\u3053\u3068\u304c\u52b9\u679c\u7684\u3067\u3042\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n<p class=\"text-center mb30 fontbold font130 text-cenlef\">Combination of pharmacogenomics and cellular pharmacogenomics<br \/>\n in Phase-II clinical trial is the key to improve its success rate<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology04-1.jpg\" alt=\"Phase-II clinical trial\u306e\u753b\u50cf\" width=\"600\" height=\"193\" class=\"aligncenter size-full wp-image-193\" srcset=\"https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology04-1.jpg 600w, https:\/\/cytopathfinder.com\/cp-bin\/wordpress5\/wp-content\/uploads\/2022\/11\/technology04-1-300x97.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/p>\n<p class=\"fontbold mb15 w80 margin-center\">Genome-wide PGx depends on the size of well-defined patients population: If the populations is not large enough, readout of signals from the noises is not easy. Biological roles of genes (markers) identified for classification of sub-population are often unclear.<\/p>\n<p class=\"fontbold mb30 w80 margin-center\">Cellular PGx can narrow down the gene network responsible for MOA of drug by silencing individual genes in genome-wide functional assay. Therefore, the combination of PGx and Cellular PGx is complementary to identify sub-populations responding \/ not responding to drug.<\/p>\n<p class=\"mb50\">\u5f93\u6765\u306ePGx\u304c\u3001\u85ac\u304c\u52b9\u304f\u4eba\uff08\u30ec\u30b9\u30dd\u30f3\u30c0\u30fc\uff09\u30fb\u52b9\u304b\u306a\u3044\u4eba\uff08\u30ce\u30f3\u30ec\u30b9\u30dd\u30f3\u30c0\u30fc\uff09\u3092\u907a\u4f1d\u30de\u30fc\u30ab\u30fc\u3092\u7528\u3044\u3066\u5224\u5225\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001\u7d30\u80dePGx\u3067\u306f\u3001\u4f8b\u3048\u3070\u3001\u3042\u308b\u60a3\u8005\u3055\u3093\u7531\u6765\u306e\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u3066\u3001\u305d\u306e\u60a3\u8005\u3055\u3093\u306ba\u85ac\u306f\u52b9\u304f\u306e\u306b\u3001b\u85ac\u306f\u52b9\u304b\u306a\u3044\u306e\u306f\u300c\u306a\u305c\u300d\u304b\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306ePGx\u306f\u3001\u30ec\u30b9\u30dd\u30f3\u30c0\u30fc\u3067\u3042\u308b\u60a3\u8005\u3055\u3093\u306b\u52b9\u304f\u85ac\u3092\u51e6\u65b9\u3059\u308b\u6307\u91dd\u306b\u306f\u306a\u308a\u307e\u3059\u304c\u3001\u30ce\u30f3\u30ec\u30b9\u30dd\u30f3\u30c0\u30fc\u306e\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u3066\u306f\u4f55\u3089\u5f79\u306b\u7acb\u3061\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u3042\u308b\u85ac\u5264\u306b\u5bfe\u3057\u3066\u30ce\u30f3\u30ec\u30b9\u30dd\u30f3\u30c0\u30fc\u3067\u3042\u308b\u60a3\u8005\u3055\u3093\u306f\u3001\u30ec\u30b9\u30dd\u30f3\u30c0\u30fc\u306e\u60a3\u8005\u3055\u3093\u3088\u308a\u3082\u5e38\u306b\u306f\u308b\u304b\u306b\u591a\u3044\u306e\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u6297\u304c\u3093\u5264\u958b\u767a\u306e\u73fe\u72b6\u306b\u5bfe\u3057\u3066\u3001\u5f53\u793e\u306e\u7d30\u80dePGx\u306f\u3001\u4f75\u5408\u5264\u3084\u9069\u5fdc\u62e1\u5927\u306e\u8a2d\u8a08\u306b\u3088\u3063\u3066\u3001\u30ce\u30f3\u30ec\u30b9\u30dd\u30f3\u30c0\u30fc\u3067\u3042\u308b\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u306b\u3082\u4f7f\u3063\u3066\u3044\u305f\u3060\u3051\u308b\u6297\u304c\u3093\u5264\u3092\u63a2\u7d22\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u304f\u3082\u306e\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n<p class=\"mb50\">\u60a3\u8005\u3055\u3093\u304b\u3089\u5f97\u3089\u308c\u305f\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u306b\u5bfe\u3057\u3001\u4f8b\u3048\u3070\u3001\u5019\u88dc\u5316\u5408\u7269\u30923\u901a\u308a\u306e\u6295\u4e0e\u91cf\u30677,000\u907a\u4f1d\u5b50\uff081\u3064\u306e\u907a\u4f1d\u5b50\u306b\u5bfe\u30574\u901a\u308a\u306esiRNA\u3092\u4f7f\u7528\uff09\u3092\u7528\u3044\u3066\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u3059\u308b\u5834\u5408\u3001384\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\u306e\u30a6\u30a7\u30eb\u30d7\u30ec\u30fc\u30c8\u3067\u306f\u30011\u30a6\u30a7\u30eb\u5f53\u308a3,000\uff5e5,000\u3082\u306e\u7d30\u80de\u304c\u5fc5\u8981\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u305f\u3081\u3001\u5b9f\u9a13\u3092\u884c\u3046\u3053\u3068\u306f\u73fe\u5b9f\u7684\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u30b5\u30a4\u30c8\u30d1\u30b9\u30d5\u30a1\u30a4\u30f3\u30c0\u30fc\u793e\u306e\u6280\u8853\u306b\u3088\u3063\u3066\u30011536\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\u30671\u30a6\u30a7\u30eb\u5f53\u308a300\uff5e500\u7d30\u80de\u30013456\u30a6\u30a7\u30eb\u3067\u306f100\uff5e150\u7d30\u80de\u3067\u5b9f\u9a13\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u306e\u3088\u3046\u306a\u5e0c\u5c11\u306a\u7d30\u80de\u8cc7\u6e90\u3092\u7528\u3044\u3066\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u5341\u5206\u306a\u6570\u306e\u30c7\u30fc\u30bf\u3092\u5f97\u308b\u3053\u3068\u304c\u3001\u521d\u3081\u3066\u73fe\u5b9f\u306e\u3082\u306e\u3068\u306a\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"\u57fa\u76e4\u6280\u8853 \u56fa\u76f8\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3STF\u306e\u6982\u8981 \u6838\u9178\u3092\u30ac\u30e9\u30b9\u30a2\u30ec\u30a4\u53c8\u306f\u7d30\u80de\u57f9\u990a\u6a39\u8102\u30d7\u30ec\u30fc\u30c8\u4e0a\u306b\u56fa\u76f8\u5316\u3057\u3066\u3001\u7d30\u80de\u3078\u306e\u6838\u9178\u5c0e\u5165\u3092\u5bb9\u6613\u306b\u3059\u308b\u6280\u8853\u306f\u30012000\u5e74\u4ee3\u521d\u982d\u306b\u5f0a\u793e\u5275\u696d\u8005\u306e\u4e00\u4eba\u3067\u3042\u308b\u7814\u7a76\u8005\u304c\u7c73\u56fd\u3000\u30b9\u30af\u30ea\u30d7\u30b9\u7814\u7a76\u6240\u3067\u958b\u767a\u7279 [&hellip;]","protected":false},"author":1,"featured_media":0,"parent":49,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-51","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/cytopathfinder.com\/ja\/wp-json\/wp\/v2\/pages\/51","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cytopathfinder.com\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cytopathfinder.com\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cytopathfinder.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cytopathfinder.com\/ja\/wp-json\/wp\/v2\/comments?post=51"}],"version-history":[{"count":26,"href":"https:\/\/cytopathfinder.com\/ja\/wp-json\/wp\/v2\/pages\/51\/revisions"}],"predecessor-version":[{"id":172,"href":"https:\/\/cytopathfinder.com\/ja\/wp-json\/wp\/v2\/pages\/51\/revisions\/172"}],"up":[{"embeddable":true,"href":"https:\/\/cytopathfinder.com\/ja\/wp-json\/wp\/v2\/pages\/49"}],"wp:attachment":[{"href":"https:\/\/cytopathfinder.com\/ja\/wp-json\/wp\/v2\/media?parent=51"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}